Skeletal Muscle Mass, Sarcopenia & Metabolic Disease Association


Sarcopenia is a condition characterized by a progressive and generalized loss of skeletal muscle mass, strength, and/or physical performance [1]. The overall prevalence of sarcopenia among Korean women over the age of 50 years is estimated as 20.2% [2]. In recent years, researchers have come to regard sarcopenia not only as a part of aging, but also as a progressive disease associated with metabolic disorders such as metabolic syndrome, diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. Several cross-sectional and longitudinal studies have reported that sarcopenia is a novel risk factor for the development of metabolic diseases. Furthermore, the pathophysiology of sarcopenia and metabolic diseases is complex, involving several processes, and has not been completely elucidated. Herein, we review the possible mechanisms underlying sarcopenia and metabolic diseases.


Due to the aging of society, sarcopenia—a condition characterized by progressive and generalized loss of skeletal muscle mass and strength that places individuals at risk for physical disability, poor quality of life, and death—has been drawing increased attention. Many studies have linked the common mechanisms underlying sarcopenia and metabolic disease, including insulin resistance and obesity, and recently, low relative skeletal muscle mass and its decline over time have been established as causative risk factors for metabolic syndrome and NAFLD. Further studies are warranted to elucidate the effects of interventions including physical exercise and nutritional supplementation on both sarcopenia and metabolic disease


It seems there is a correlation to a sedentary-lifestyle & metabolic disease and Non-Alcoholic Fatty Liver Disease, accompanied by a higher amount of body fat. Metabolic Disease seems to have a large association to higher body fat, and higher body fat can be found an aging population for many reasons, one being because of the decline in muscle mass as we age(sarcopenia), assuming we’re not resistance training or working out in general.

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